Bones & Joint

DOSAGE:

252.5 mg/ml

PACKAGE CONTENT:

1 vial containing 252.5 mg/ml of active compounds.

WHAT IS IT:

Bones & Joint is a restorative formula designed to support joint health, promote bone strength, and enhance tissue repair. It contains a blend of amino acids and antioxidants that work synergistically to improve connective tissue function and recovery.

  • N-Acetylcysteine (50 mg): A powerful antioxidant that reduces oxidative stress and inflammation, supporting tissue repair and joint health.
  • L-Proline (50 mg): An essential component of collagen production, which strengthens joints, tendons, and ligaments.
  • L-Histidine (25 mg): Helps reduce inflammation and supports tissue repair.
  • Glycine (25 mg): Improves collagen synthesis, enhances joint flexibility, and aids in muscle recovery.
  • L-Lysine (25 mg): Boosts collagen production and promotes calcium absorption for stronger bones.
  • L-Leucine (15 mg): Supports muscle repair and prevents tissue breakdown.
  • L-Isoleucine (10 mg): Aids in tissue healing and reduces inflammation in joints.
  • L-Valine (40 mg): Promotes muscle recovery and enhances joint mobility by supporting protein synthesis.

HOW TO USE:

  • Recommended Dosage: Inject 1 ml subcutaneously or intramuscularly, 2–3 times per week, based on joint and bone health needs.
  • Administration: Can be taken subq or IM, preferably IM to avoid skin irritation.

BATCH INFORMATION:
Batch No: DR22154
Manufacturing date: 03.2024.
Expiry date: 03.2027.

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Scientific information, insights and considerations about taking MK-677 (Ibutamoren)

Endocrine Effects and Action Mechanism

MK-677 (Ibutamoren) is classified as an orally active growth hormone secretagogue (GHS) which mimics ghrelin’s action, by binding to ghrelin receptors and prompting the pituitary gland to increase growth hormone (GH) release. This in turn elevates insulin-like growth factor 1 (IGF-1) levels. Research studies available have reported significant and sustained increases in both GH and IGF-1 after daily administration. From available research – one randomized, double-blind, placebo-controlled trial found that MK-677 increased mean 24-hour GH and serum IGF-1 concentrations by up to 40% after several weeks of continued use.

Body Composition and Metabolic Considerations

Enhancement of the GH/IGF-1 axis can lead to improvements in lean muscle mass, bone mineral density, and potentially alter fat distribution. In older adults, MK-677 administration has been correlated with increased fat-free mass and improved nitrogen balance, suggesting favorable effects on protein metabolism and overall health. However, as a ghrelin mimetic, MK-677 often increases appetite, making careful dietary and caloric management crucial for individuals aiming for specific physique or performance goals and use of Ibutamoren on its own does not guarantee improvements in body composition.

How MK-677 can potentially affect sleep quality and cognitive function

According to the available research – data indicates that MK-677 can improve sleep quality, particularly by increasing slow-wave (deep) sleep duration. Improvements in sleep can have a positive impact on mood, cognitive performance, and recovery from exercise. Although more large-scale, randomized studies are needed, these early findings suggest that MK-677’s endocrine effects may extend beyond body composition and result in other non-body composition related aspects.

Ibutamoren’s Influence on Hormonal Balance and Metabolic Health

According to the available research, MK-677 does not appear to significantly suppress testosterone production, focusing primarily on the GH/IGF-1 axis, indicating that its use might be a better alternative to conventional steroids, if you are concerned with testosterone suppression. Despite that, subtle metabolic changes—such as variations in insulin sensitivity—may occur after prolonged use. Users should monitor their metabolic markers over time and make adjustments to their dosage as needed.

Safety Parameters in regards to Lipid Profiles and Glucose Metabolism

Ibutamoren’s long-term effects on lipid profiles and glucose metabolism remain under investigation. According to the research available, some individuals may experience shifts in fasting blood glucose or cholesterol levels. If you are concerned about the effects, regular or periodic laboratory assessments can help detect any unfavorable metabolic trends early on.

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