Nandrolone Phenylpropionate (NPP)

DOSAGE:
Nandrolone phenylpropionate (NPP) 100mg/ml

PACKAGE CONTENT:
1 x 10ML vial, 100 mg per ml

WHAT IS IT:
Nandrolone is a widely used steroid belonging to the 19 nors family.

19-Nors are generally characterized by their anabolism and progestogenic activity.
They are very anabolic, but they also exhibit significant amounts of satellite interaction with other receptors in the body.

The most notable being their interaction with the Progesterone receptor.
19-Nor derived progestins are agonists of the Progesterone receptor, which means that they can bind to the Progesterone receptor and activate it.

Nandrolone causes a reduction in the ability to perceive pain (which increase is confused with a healing effect) and can also be reduced to DHN, DHN can displace DHT from its receptors causing several side effects, among which mood swings stand out and absence of erections, this can be remedied using Masteron, Proviron or some other steroid that reacts directly with the androgen receptor through DHT.

HOW TO USE:
Normal doses are usually 200 to 400 mg per week for beginners and intermediate athletes, with the possibility of using 800 per week for specific or competitive purposes.

Since it has a short ester it is recommended to inject it ED or EOD.

BATCH INFORMATION:
Batch No: LE81578
Manufacturing date: 03.2023.
Expiry date: 03.2026.

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Scientific information, insights and considerations about taking MK-677 (Ibutamoren)

Endocrine Effects and Action Mechanism

MK-677 (Ibutamoren) is classified as an orally active growth hormone secretagogue (GHS) which mimics ghrelin’s action, by binding to ghrelin receptors and prompting the pituitary gland to increase growth hormone (GH) release. This in turn elevates insulin-like growth factor 1 (IGF-1) levels. Research studies available have reported significant and sustained increases in both GH and IGF-1 after daily administration. From available research – one randomized, double-blind, placebo-controlled trial found that MK-677 increased mean 24-hour GH and serum IGF-1 concentrations by up to 40% after several weeks of continued use.

Body Composition and Metabolic Considerations

Enhancement of the GH/IGF-1 axis can lead to improvements in lean muscle mass, bone mineral density, and potentially alter fat distribution. In older adults, MK-677 administration has been correlated with increased fat-free mass and improved nitrogen balance, suggesting favorable effects on protein metabolism and overall health. However, as a ghrelin mimetic, MK-677 often increases appetite, making careful dietary and caloric management crucial for individuals aiming for specific physique or performance goals and use of Ibutamoren on its own does not guarantee improvements in body composition.

How MK-677 can potentially affect sleep quality and cognitive function

According to the available research – data indicates that MK-677 can improve sleep quality, particularly by increasing slow-wave (deep) sleep duration. Improvements in sleep can have a positive impact on mood, cognitive performance, and recovery from exercise. Although more large-scale, randomized studies are needed, these early findings suggest that MK-677’s endocrine effects may extend beyond body composition and result in other non-body composition related aspects.

Ibutamoren’s Influence on Hormonal Balance and Metabolic Health

According to the available research, MK-677 does not appear to significantly suppress testosterone production, focusing primarily on the GH/IGF-1 axis, indicating that its use might be a better alternative to conventional steroids, if you are concerned with testosterone suppression. Despite that, subtle metabolic changes—such as variations in insulin sensitivity—may occur after prolonged use. Users should monitor their metabolic markers over time and make adjustments to their dosage as needed.

Safety Parameters in regards to Lipid Profiles and Glucose Metabolism

Ibutamoren’s long-term effects on lipid profiles and glucose metabolism remain under investigation. According to the research available, some individuals may experience shifts in fasting blood glucose or cholesterol levels. If you are concerned about the effects, regular or periodic laboratory assessments can help detect any unfavorable metabolic trends early on.

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