Tamoxifen Citrate

DOSAGE:
Tamoxifen citrate 20mg/tab

PACKAGE CONTENT:
1 satchet, 50 tabs, 20mg per tab

WHAT IS IT:
Tamoxifen citrate is a selective estrogen receptor modulator. Selective estrogen receptor modulators can act as estrogen receptor agonists or antagonists.

This activity of tamoxifen citrate is tissue selective, effecting those estrogen receptors located in the liver, breast, and bone.
When the tamoxifen molecule binds to this receptor, the estrogen is blocked and can’t have any effect.

For bodybuilders Tamoxifen citrate can help in two ways.
Firstly due to the binding affinity of the compound it is able to help in the prevention of gynecomastia. Tamoxifen will compete with estrogen for the estrogen receptors in certain tissues, including the breast, and if it can bind to the receptor estrogen will not have an opportunity to interact with receptor and therefore gynocomastia should not be able to develop.

The second, and possibly more beneficial, aspect of tamoxifen citrate for steroid users is its ability to increase the production of luteinizing hormone and follicle stimulating hormone, and therefore increasing testosterone. This ability is why it is
often used by steroid users during their post-cycle therapy.

HOW TO USE:
The dose to treat both gynecomastia and to be used in PCT varies between 20-40mg per day, the dose has to be adjusted until the desired effect is achieved.

BATCH INFORMATION:
Batch No: CA93254
Manufacturing date: 03.2023.
Expiry date: 03.2026.

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Scientific information, insights and considerations about taking MK-677 (Ibutamoren)

Endocrine Effects and Action Mechanism

MK-677 (Ibutamoren) is classified as an orally active growth hormone secretagogue (GHS) which mimics ghrelin’s action, by binding to ghrelin receptors and prompting the pituitary gland to increase growth hormone (GH) release. This in turn elevates insulin-like growth factor 1 (IGF-1) levels. Research studies available have reported significant and sustained increases in both GH and IGF-1 after daily administration. From available research – one randomized, double-blind, placebo-controlled trial found that MK-677 increased mean 24-hour GH and serum IGF-1 concentrations by up to 40% after several weeks of continued use.

Body Composition and Metabolic Considerations

Enhancement of the GH/IGF-1 axis can lead to improvements in lean muscle mass, bone mineral density, and potentially alter fat distribution. In older adults, MK-677 administration has been correlated with increased fat-free mass and improved nitrogen balance, suggesting favorable effects on protein metabolism and overall health. However, as a ghrelin mimetic, MK-677 often increases appetite, making careful dietary and caloric management crucial for individuals aiming for specific physique or performance goals and use of Ibutamoren on its own does not guarantee improvements in body composition.

How MK-677 can potentially affect sleep quality and cognitive function

According to the available research – data indicates that MK-677 can improve sleep quality, particularly by increasing slow-wave (deep) sleep duration. Improvements in sleep can have a positive impact on mood, cognitive performance, and recovery from exercise. Although more large-scale, randomized studies are needed, these early findings suggest that MK-677’s endocrine effects may extend beyond body composition and result in other non-body composition related aspects.

Ibutamoren’s Influence on Hormonal Balance and Metabolic Health

According to the available research, MK-677 does not appear to significantly suppress testosterone production, focusing primarily on the GH/IGF-1 axis, indicating that its use might be a better alternative to conventional steroids, if you are concerned with testosterone suppression. Despite that, subtle metabolic changes—such as variations in insulin sensitivity—may occur after prolonged use. Users should monitor their metabolic markers over time and make adjustments to their dosage as needed.

Safety Parameters in regards to Lipid Profiles and Glucose Metabolism

Ibutamoren’s long-term effects on lipid profiles and glucose metabolism remain under investigation. According to the research available, some individuals may experience shifts in fasting blood glucose or cholesterol levels. If you are concerned about the effects, regular or periodic laboratory assessments can help detect any unfavorable metabolic trends early on.

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